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Internal bleeding in other systems i.e. gastrointestinal, genitourinary, and respiratory ; can occur and may require cessation of treatment depending on severity Genetech, 2004 ; . Cerebral edema, cerebral herniation, seizure, and new ischemic stroke have been reported among patients receiving t-PA; however, these reactions may be associated with the occurrence of the stroke rather than a consequence of the thrombolytic therapy Genetech, 2004 ; . Though rare, a syndrome of severe angioedema is also a potential risk, especially for patients taking angiotensin converting enzyme inhibitors Chodirker, 2000 ; . Mild superficial bleeding usually occurs with treatment and is observed mainly at invaded or disturbed sites such as an IV catheter insertion site or needle puncture sites. Other minor and less frequently reported reactions include gingival hemorrhage, bruising, and allergic reactions Genetech, 2004 ; . To reduce the potential for serious side effects, possible drug interactions are important to understand, especially drugs that may affect homeostasis and thus enhance the potential for bleeding. Persons should not be given antithrombotic or antiplatelet aggregating drugs within 24 hours of t-PA therapy AAN, 1996 ; . The following drugs may increase the risk of hemorrhage and thus should be used with caution: heparin, aspirin, warfarin or oral anticoagulants, and drugs that affect platelet function such as: NSAIDs Ticlopidine Ticlid ; Clopidogrel Plaivx ; Genetech, 2004 and prevacid. 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