Catherine A. Marco, MD, FACEP Clinical Professor, University of Toledo College of Medicine; Attending Physician, St. Vincent Mercy Medical Center, Toledo, Ohio.
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Gery, rats were injected s.c. with 0.04 mg kg apomorphine, and the number of contralateral rotations were recorded during a 1-h period immediately after injection. The criteria for the inclusion of animals in subsequent experiments was a minimum of 10 contralateral rotations during a 10-min period. Rotational Behavior Testing. To measure the activity of compounds on spontaneous circling behavior, rats were placed in a cylindrical cage 240 mm in diameter, 300 mm high ; and the number of rotations, both ipsilateral and contralateral, was recorded using an automatic rotometer Rota-Count-8; Columbus Instruments ; during a 1-h period immediately after drug or vehicle injection. To study the effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior induced by the dopaminergic compounds, rats were placed in the cylindrical cages, and circling behavior was assessed for a 1-h period immediately after an administration of 0.04 mg kg s.c. apomorphine or 2.5 mg kg s.c. methylphenidate. Animals were injected i.p. with the alpha-2 adrenoceptor compounds or vehicle 5 min before the administration of dopaminergic drugs. The total number of animals tested per dose was five. Drugs. The following compounds were synthesized at the Center de Recherche Pierre Fabre Castres, France ; : UK 14304 tartrate 5-bromo-6[2-imidazoline-2-yl amino] quinoxaline ; , idazoxan tartrate 2-[2- 1, 4-benzodioxanyl ; ]-2 imidazoline ; , ; -efaroxan hydrochloride 2-[2- 2-ethyl-2, 3-dihydrobenzofuranyl ; ]-2 imidazoline ; , ; efaroxan hydrochloride, and ; -efaroxan hydrochloride. The other drugs used were clonidine hydrochloride Sigma, Saint Quentin Fallavier, France ; , desipramine hydrochloride Sigma ; , 6-OHDA hydrochloride 6-hydroxydopamine; Sigma ; , ketamine hydrochloride Clorketam 1000, Vetoquinol ; , methylphenidate hydrochloride CibaGeigy Co. ; , and R- ; -apomorphine hydrochloride Research Biochemicals Inc., Illkirch, France ; . 6-OHDA was freshly prepared in saline containing 0.2% ascorbic acid. All other drugs were dissolved in distilled water. An injection volume of 10 ml was used throughout. Doses refer to the free base, and were selected from the geometrical series 0.01, 0.04, 0.16, and 10 mg kg. Statistics. All results were compared using a Kruskal-Wallis nonparametric one-way analysis of variance corrected for ties followed by a two-tailed Mann-Whitney U test GB-STAT; Friedman, 1991 ; . Results were, however, expressed as the mean S.E.M. in spite of the probable non-normality of the distribution of scores, because it was felt that these parameters provide a clearer indication for most investigators.
Local disease and recurrence When the local disease, particularly in the pelvis, cannot be removed and is causing substantial symptoms, radiotherapy and chemotherapy may be used, although the latter is more effective. Some recurrences e.g. at a suture line ; may be resectable, but this is uncommon. Hepatic metastases Some deposits in the liver are solitary and can be removed by surgery. A more radical approach is now used and has resulted in some improvement in survival. More-diffuse hepatic secondaries are treated palliatively by chemotherapy, because methylphenidate adults.
The most effective treatment for sad is light therapy, sometimes combined with antidepressant drugs, psychotherapy talk therapy ; , or both.
Genes, attention and methylphenidate response in ADHD Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K 2000 ; Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measures by single photon emission computed tomography. Neuoscience Letters 285: 107-110 Laakso A, Vilkman H, Alakare B, Haaparanta M, Bergman J, Solin O, Peurasaari J, Rakkolainen V, Syvalahti E, Hietala J 2000 ; Striatal dopamine transporter binding in neuroleptic-naive patients with schizophrenia studied with positron emission tomography. American Journal of Psychiatry 157: 269-271 Langley K, Marshall L, Van Den Bree M, Thomas H, Owen M, O'Donovan M, Thapar A 2004 ; Association of the dopamine d 4 ; receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161: 133-138 Loo SK, Specter E, Smolen A, Hopfer C, Teale PD, Reite ML 2003 ; Functional effects of the DAT1 polymorphism on EEG measures in ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 42: 986-993 Manor I, Tyano S, Eisenberg J, Bachner-Melman R, Kotler M, Ebstein RP 2002 ; The short DRD4 repeats confer risk to attention deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test TOVA ; . Molecular Psychiatry 7: 790-794 McDonald S, Bennett KM, Chambers H, Castiello U 1999 ; Covert orienting and focusing of attention in children with attention deficit hyperactivity disorder. Neuropsychologia 37: 345-356 Mesulam M-M 1981 ; A cortical network for directed attention and unilateral neglect. Annals of Neurology 10: 309-325 and methylprednisolone.
The overall number of OC prescriptions rose 10% over the past 2 years. The most commonly prescribed formulations contain 30 or 35 mcg of estrogen. In 1998, roughly 30 million prescriptions were written for 30 mcg pills; just over 32 million 35 mcg OC prescriptions were dispensed the same year. Together, these two OC formulations account for more than 90% of the OC market Figure 2 ; . During the first half of the 1990s, prescriptions for 35 mcg pills waned as more 30 mcg products became available. In 1991, prescriptions for 35 mcg pills outnumbered those for 30 mcg OCs by nearly 2 to 1. 1996, however, clinicians were prescribing more 30 mcg pills than 35 mcg preparations. Between 1996 and 1998, the number of prescriptions for 35 mcg pills increased nearly 14%. Meanwhile, the number of 30 mcg OCs dispensed dropped slightly, down approximately 3% over the 2-year period Figure 3.
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CARDIOVASCULAR & THORACIC SURGERY PGIMER 1. Comparison of right anterolateral thoracotomy with median sternotomy for open heart surgery on atrial septum and mitral valve. Two groups of patients undergoing open heart surgery for mitral valve replacement and ASD closure were compared. In one group midsternotomy was used and in the second group right anterolateral thoracotomy the cosmetic results were better and anterolateral thoracotomy group, blood complications was used. It was found that respiratory more acceptable to the patients. In loss and post-operative.
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Efficacy and Safety of Meridia in Binge Eating Disorder A 7-Week Double-Blind, Placebo-Controlled, Randomized, Multicenter Study Evaluating the Safety & Efficacy of 3 Doses of CP-526, 555 in Comparison with Zyban SR in Smoking Cessation Modafinil Analog Classroom ADHD Study Cyberonics - HRSD Training An 8-Week Double-Blind, Randomized, Multicenter Flexible Dose Range Placebo Controlled Study of Pagoclone in Patients with Panic Disorder Safety and Efficacy of Naltrel in Treatment of Alcohol Dependence A Multicenter, Double-Blind, Placebo-Controlled Safety & Efficacy Study of MTS in Pediatric Patients with ADHD Aripiprazole vs. Perphenazine in Treatment Resistant Schizophrenia Open Venlafaxine Treatment of Dysthymic Disorder in the Elderly Neuroimaging Studies in Generalized Anxiety Disorder During Treatment with Paroxetine Evaluation od Safety and Efficacy of Viagra Citalopram Treatment of Social Phobia with Comorbid Depression Citalopram Treatment for Irritable Bowel Syndrome IBS ; Comorbid with Anxiety Disorders A Phase 2 Study of the Use of PH80 for Management of the Symptoms of Clinically Significant Premenstrual Syndrome PMS ; Acute & Extension Study of MK-0869 in Treatment of Patients w Major Depressive Disorder A Prospective Open-Label Study of Ziprasidone in the Treatment of Bipolar I Depression Noven Methylph4nidate Transdermal System Acute and Long Term Trials Multicenter Study of the Long Term Efficacy of MK-0869 in the Maintenance of Antidepressant Effect in Geriatric Outpatients. Assessing the In Vivo D2 Receptor Occupancy of IM Olanzapine Depot Pamoate ; Using PET in Patients w Schizophrenia Training and Consultation-Liaison Program Between Academic Psychiatrists and Community Based PMD's Psychometric Assessment of the Reliability and Validity of Two Outcome Measures For Use In A Chronic Spinal Cord Injury Population Nalmefene in the Treatment of Pathological Gambling. A Placebo-Controlled Dose-Response Study The Efficacy and Safety of Risperidone in the Treatment of Children and Adolescents with Schizophrenia and morphine.
Figure 3. Amplification of the VH and VL chain genes using selfdesigned primers. Amplification of the VH and VL chain genes was carried out using commercial and self-designed primers. Samples were electrophoresed on a 1% agarose in 1X TBE buffer. Lane 1: 100 bp DNA ladder Gibco BRL Lane 2: VH DNA fragment amplified using VHA and VHB primers; Lane 3: VL DNA fragment amplified using VLA and VLB primers; Lane 4: negative control where PCR amplification using VHA and VHB primer and distilled water as the template; Lane 5: VH DNA fragment amplified using VH primer 1, VH primer 2 Amersham Pharmacia Lane 6: V L DNA fragment amplified using V L primer mix Amersham Pharmacia, because order methylphenidate.
Miscellaneous Analytical Artifacts: 371 ; Varshney K-M. HPTLC study of the stability of heroin in methanol. Journal of Planar Chromatography 2002; 15 1 ; : 46. [Presents the results of a degradation study of heroin in methanol at room temperature ; . The results indicate degradation is measurable on Day 2, and is complete in around 38 weeks.] Chemometrics: 372 ; Praisler M, Van Bocxlaer J, De Leenheer A, Massart DL. Chemometric detection of thermally degraded samples in the analysis of drugs of abuse with gas chromatographyFourier-transform infrared spectroscopy. Journal of Chromatography A 2002; 962 12 ; : 161. [For the identification of the reference standard peak in cases where the GCFTIR analysis gives multiple peaks.] Cocaine: 373 ; Brachet A, Rudaz S, Mateus L, Christen P, Veuthey J-L. Optimisation [sic] of accelerated solvent extraction of cocaine and benzoylecgonine from coca leaves. Journal of Separation Science 2001; 24 10-11 ; : 865. [A variety of extraction parameters were varied to achieve the optimal results. Analysis was conducted by GC FID and CE with UV detection.] 374 ; Tanaka S, Lio R, Chinaka S, Takayama N, Hayakawa K. Analysis of reaction products of cocaine and hydrogen peroxide by high performance liquid chromatography mass spectrometry. Biomedical Chromatography 2002; 16 6 ; : 390. [Various hydroxy and dihydroxy cocaines were identified.] Counterfeit Drugs: 375 ; Rudolf PM, Bernstein IBG. Counterfeit drugs. New England Journal of Medicine 2004; 350: 1384. ; Scafi SHF, Pasquini C. Identification of counterfeit drugs using near-infrared spectroscopy. Analyst 2001; 126 12 ; : 2218. Dragon's Blood: 377 ; Edwards HGM, de Oliveira LFC, Prendergast HDV. Raman spectroscopic analysis of Dragon's Blood resins - Basis for distinguishing between Dracaena Convallariaceae ; , Daemonorops Palmae ; , and Croton Euphorbiaceae ; . Analyst 2004; 129 2 ; : 134. 378 ; Hu Y, Ning Z, Liu D. Determination of pterostilbene in Dragon's Blood by RP-HPLC. Yaowu Fenxi Zazhi 2002; 22 6 ; : 428. 379 ; Hu Y, Zhang J, Liu C-h, Deng C. Difference of Dragon's Blood from different extract processing. Zhongcaoyao 2002; 33 8 ; : 697. [Analysis by TLC, UV, and HPLC.] and naproxen.
Lortab * hydrocodone & acetaminophen ; 32 Lotensin * benazepril ; 16 Lovenox enoxaparin ; 17 Loxitane * loxapine ; 27 Lozol * indapamide ; 18 Ludiomil * maprotiline ; 27 Lumigan bimatoprost ; 24 Lupron * leuprolide ; 22, 23, 31 Luride Lozi-Tabs sodium fluoride ; 30 Luvox * fluvoxamine ; 27 Lysodren mitotane ; 31 Macrodantin * nitrofurantoin ; 16 Malarone atovaquone & proguanil ; 16 Marinol dronabinol ; 25 Matulane procarbazine ; 31 Maxalt-MLT rizatriptan ; 32 Maxitrol * neomycin polymixin B dexamethasone ; 23 Maxzide * hydrochlorothiazide & triamterene ; 18 Meclomen * meclofenamate ; 32 Medrol * methylprednisolone ; 21 Megace * megestrol ; 31 Melanex * hydroquinone ; 20 Mellaril * thioridazine ; 27 Mephyton phytonadione or vitamin K1 ; .30 Mesnex * mesna ; 31 Mestinon pyridostigmine ; 29 Metadate ER * methylphenidate ; 28 Methergine methylergonovine ; 23 Metopirone metyrapone ; 23 MetroCream + metronidazole ; 14 MetroGel + metronidazole 0.75% ; .14 MetroGel metronidazole 1% ; 14 MetroGel Vaginal * metronidazole ; 16 MetroLotion + metronidazole ; 14 Mevacor * lovastatin ; 17 Mexitil * mexiletine ; 18 Microgestin Fe 1 20 & 1.5 30 + ethinyl estradiol & norethindrone ; 20 Micronase * glyburide ; 22 Micronor * norethindrone ; 20 Midrin * isometheptene dichloral-phenazone acetaminophen ; 32 Mifeprex mifepristone ; 23 Migranal dihydroergotamine ; 32 Minipress * prazosin ; 18, 35 Minitran nitroglycerin ; 18 Minocin * minocycline ; 13 MiraLax * polyethylene glycol ; 25 Mirapex pramipexole ; 28 Mirena IUD levonorgestrel ; 21 Moban molindone ; 27 Mobic * meloxicam ; 32 Modicon * ethinyl estradiol & norethindrone ; 20 Monoket * isosorbide mononitrate ; 18 morphine sulfate * 32 Motrin * ibuprofen ; 32 MS Contin morphine SR ; .32 Mucomyst acetylcysteine ; 34 Myambutol * ethambutol ; 16 Mycelex * clotrimazole ; 14, 25 Mycobutin rifabutin ; 16 Mycolog II * nystatin & triamcinolone ; 14 Mycostatin * nystatin ; 14, 16.
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Not require cell mitosis but is likely to involve transition of bordering keratinocytes from a resting state to a wound phenotype in an effort to close a breached basement membrane, similar to macroscopic wound repair processes [29, 36]. MENDs collect beneath the corneal layer within 24 hours where they persist for up to 2 weeks, correlating with observed clinical bronzing. Based on histology, lack of TEWL changes, and clinical observations following FP treatment, it appears that skin barrier function is preserved, achieved both by a relative sparing of the stratum corneum during laser exposure and the fact that collections of MENDs do not seem to alter normal corneocyte biology. This deserves further study. Preservation of barrier function following treatment may explain the lack of clinically evident oozing and crusting and the absence of skin infections noted. As MTZ density approaches a critical value in this study, near 125 mm center-to-center MTZ separation ; , the dose-response curve for FP appears to steepen. We noted this effect in the forearm study at high MTZ density. Further studies are planned to investigate the MTZ wound repair phenomenon in more detail. The effects of FP on epidermal pigment are of interest because current non-ablative treatments in the infrared region have little or no effects on epidermal pigmented lesions, and ablative techniques remove the complete pigmented layer which results in prolonged pigmentary perturbation [35]. In our study, there were several dark skinned subjects, who demonstrated little or no significant pigmentation abnormalities after FP at low or medium MTZ densities per treatment. Histology revealed that there is a localized, well-controlled melanin release and transport mechanism using MENDs as a ``vehicle.'' Unwanted localized accumulations of pigment e.g., solar lentigines ; appear to be effectively removed in a precise and gradual manner as observed in the periorbital study see Fig. 6CF and Table 5 ; . Further investigation regarding this aspect of FP may offer new concepts for treatment of dyschromia. The dermal component of MTZ repair involves removal and replacement of necrotic cellular materials and denatured extracellular matrix in a relatively prolonged process that does not appear to involve a classical ``inflammatory'' phase of wound repair. While histology samples from biopsies taken both 1 day and 1 week post exposure show little evidence of significant inflammatory cell infiltration, the immediate erythema and induration observed clinically following treatment Table 3 ; are consistent with the generation and release of wound mediators in both epidermal and dermal compartments. Remodeling of matrix components was apparent by 3 months, at which time increased mucin staining was observed in the.
Patients: A series of 16 patients diagnosed with traumatic brain injury n 12 ; and subarachnoid hemorrhage n 4 ; were followed before and after taking methylphenidate, as a part of treatment for clinically identified attentional deficit. Results: The introduction of methylpbenidate correlated with an improvement in processing speed loss, divided attention loss, and selective attention loss on the UFOV test. M4thylphenidate use was further correlated with improvement on FIM Cognition and FIM Activity of Daily Living subscales. Conclusions: Meghylphenidate use, in an inpatient population of patients with ABI, resulted in a significant improve61 and neurontin.
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Clinical Implications Persistence with methylpyenidate MPH ; therapy is lower in a general population setting than in closely supported clinical or research cohorts; this supports the need for close follow-up and support of patients on stimulant therapy. Lack of persistence may be more of an issue among girls, who may therefore need even closer support and supervision. Discontinuities during a child's course of stimulant therapy are relatively frequent. Clinicians should enquire about these and try to understand the reasons for them. Limitations Results reflect persistence with MPH, which was the main stimulant in use at the time of the study. The extent of persistence with stimulant drugs as a group may be somewhat higher than is reported here. The advent of new agents for treating attention-deficit hyperactivity disorder may affect persistence patterns. Use of administrative data does not allow us to understand persistence or lack of persistence ; at the individual patient level and norvasc and methylphenidate.
Keywords: histamine; methylphenidate; atomoxetine; adhd; microdialysis corresponding author.
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Figure 1 figure mean methyylphenidate plasma concentrations in 36 adults, following a single dose of concerta® 18 mg qd and immediate-release methylphenidate 5 mg tid administered every 4 hours the mean pharmacokinetic parameters in 36 adults following the administration of concert a® 18 mg qd and methylphenidate 5 mg tid are summarized in table table 1: mean ± sd pharmacokinetic parameters concerta® 18 mg qd ; n 36 ; methylphenidate 5 mg tid ; n 35 ; no differences in the pharmacokinetics of concerta® were noted following single and repeated once-daily dosing indicating no significant drug accumulation.
Analysis conducted by the Guild shows that females still predominate once figures have been adjusted to allow for total male female population numbers in various age cohorts. Table 2.9 lists the number of Item 900 services per 100, 000 people by gender and age cohort.
This protocol is to be used for those patients suspected of exposure to toxic substances via any route of exposure ie. drug overdose, snake bite, etc. ; . The protocols will give specific considerations for each type of exposure, as well as general treatment guidelines. Additional assistance may be necessary in certain cases ie. hazardous materials team for toxic exposure, police for scene control, including violent and or impaired patient - see Adult Protocol 2.5.2 ; . A history of the events leading to the illness or injury should be obtained from the patient and bystanders to include: 1. What drugs, poisons, or other substance s ; was the patient exposed? Consider multiple substances, especially on overdoses. Route of exposure? When and how much? Duration of symptoms? Is patient depressed, suicidal? History of previous overdose? if applicable ; . Accidental? Nature of accident? Duration of exposure if applicable.
To top adverse effects nervousness and insomnia are the most common adverse reactions reported with methylphenidate but are usually controlled by reducing dosage and omitting the drug in the afternoon or evening.
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Industry in Ireland. Later in the month on 21 22 January, the CEO of the IMB, Mr Pat O'Mahony, chaired meetings of Heads of Agencies and Heads of Veterinary Regulatory Authorities. The informal meetings of the Committee for Proprietary Medicinal Products, the Committee for Orphan Medicinal Products and the Mutual Recognition Facilitation Group were held in Dublin on 29 30 April. Further meetings are planned for later in the six months' period of the presidency.
These guidelines are directed at the management of back pain in primary health care settings. Effective collaboration with those providing occupational health services, managers responsible for defining the tasks undertaken at work and social security administrations may be required whenever back pain occurs in people of working age. This appendix outlines the contributions which good occupational health practice can make to back pain management and identifies where the evidence base for such practice can be found. Detailed guidelines are not presented as these will vary considerably between member states depending on the provisions for occupational health and social security.
The patients received three treatment courses in a crossover design consisting of concerta once-daily, methylphenidate immediate release three times per day over a period of 12 hours, and placebo.
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Patients with an element of agitation may react adversely; discontinue therapy if necessary. Periodic CBC, differential, and platelet counts are advised during prolonged therapy. Drug treatment is not indicated in all cases of this behavioral syndrome and should be considered only in light of the complete history and evaluation of the child. The decision to prescribe Methylin should depend on the physician's assessment of the chronicity and severity of the child's symptoms and their appropriateness for his her age. Prescription should not depend solely on the presence of one or more of the behavioral characteristics. When these symptoms are associated with acute stress reactions, treatment with Methylin is usually not indicated. Long-term effects of Methylin in children have not been well established. Drug Interactions Methylin may decrease the hypotensive effect of guanethidine. Use cautiously with pressor agents. Human pharmacologic studies have shown that Methylin may inhibit the metabolism of coumarin anticoagulants, anticonvulsants phenobarbital, diphenylhydantoin, primidone ; , phenylbutazone, and tricyclic drugs imipramine, clomipramine, desipramine ; . Downward dosage adjustments of these drugs may be required when given concomitantly with Methylin. Serious adverse events have been reported in concomitant use with clonidine, although no causality for the combination has been established. The safety of using methylphenidate in combination with clonidine or other centrally acting alpha-2 agonists has not been systemically evaluated. Carcinogenesis, Mutagenesis, Impairment of Fertility In a lifetime carcinogenicity study carried out in B6C3F1 mice, methylphenidate caused an increase in hepatocellular adenomas and, in males only, an increase in hepatoblastomas, at a daily dose of approximately 60 mg kg day. This dose is approximately 30 times and 2.5 times the maximum recommended human dose on a mg kg and mg m2 basis, respectively. Hepatoblastoma is a relatively rare rodent malignant tumor type. There was no increase in total malignant hepatic tumors. The mouse strain used is sensitive to the development of hepatic tumors, and the significance of these results to humans is unknown. Metthylphenidate did not cause any increase in tumors in a lifetime carcinogenicity study carried out in F344 rats; the highest dose used was approximately 45 mg kg day, which approximately 22 times and 4 times the maximum recommended human dose on a mg kg and mg m2 basis, respectively. Methylphenidate was not mutagenic in the in vitro Ames reverse mutation assay or in the in vitro mouse lymphoma cell forward mutation assay. Sister chromatid exchanges and chromosome aberrations were increased, indicative of a weak clastogenic response, in an in vitro assay in cultured Chinese Hamster Ovary CHO ; cells. The genotoxic potential of methylphenidate has not been evaluated in an in vivo assay. Usage in Pregnancy Adequate animal reproduction studies to establish safe use of Methylin during pregnancy have not been conducted. However, in a recently conducted study, methylphenidate has been shown to have teratogenic effects in rabbits when given in doses of 200 mg kg day, which is approximately 167 times and 78 times the maximum recommended human dose on a mg kg and a mg m2 basis, respectively. In rats, teratogenic effects were not seen when the drug was given in doses of 75 mg kg day, which is approximately 62.5 and 13.5 times the maximum recommended human dose on a mg kg and a mg m2 basis, respectively. Therefore, until more information is available, methylphenidate should not be prescribed for women of childbearing age unless, in the opinion of the physician, the potential benefits outweigh the possible risks.
Pharmacology: Concerta XL employs an osmotic pump system OROS ; , which has been designed to have a12-h duration of effect. An 18 mg tablet includes a shell of 4 mg immediate-release i.e. 22% ; . In clinical trials, Concerta XL has been shown to be as effective as 3-times-a-day methylphenidate [48, 80]. However, a 20% higher dose of Concerta XL was required in the Pelham et al. [48] study.
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As "High and New Technology Enterprise" to which a preferential tax rate of 15% applies and are entitled to an income tax exemption for two years commencing from the first profitable year after deducting losses carried forward ; , and a 50% reduction for the succeeding three years. If these Foreign Investment Enterprises are qualified as "Advanced Technology Enterprises", they can extend three more years for 50% tax reduction, and the minimum tax rate should not be lower than 10%. The Group's principal operating subsidiaries are qualified as "Advanced Technology Enterprises". As of 30 September, 2005, JCTT, the principal operating subsidiaries and Beijing Tide, a jointly-controlled entity of the Group are subject to an income tax rate of 10% and 12% respectively 2004: JCTT: 10%; Beijing Tide: 12% ; . 7 ; Dividends The Board has declared the third quarterly dividend of HK1.5 cents per ordinary share for the nine months ended 30 September, 2005 2004: HK1.33 cents per ordinary share, after adjusted for the effect of issue of bonus shares ; . The Board has also declared the special dividend of HK5 cents per ordinary share. Both the third quarterly dividend and the special dividend will be paid to shareholders on Thursday, 8 December, 2005 whose names appear on the Register of Members of the Company on Thursday, 1 December, 2005. The Register of Members of the Company will be closed from Tuesday, 29 November, 2005 to Thursday, 1 December, 2005 both days inclusive ; , during which period no transfer of share of the Company will be effected. In order to qualify for the third quarterly dividend and special dividend, all transfers accompanied by the relevant share certificates must be lodged with the Company's branch share registrar, Tengis Limited, G F., Bank of East Asia Harbour View Centre, 56 Gloucester Road, Wanchai, Hong Kong by 4: 00 p.m. on Monday, 28 November, 2005. 8 ; Earnings per share The calculation of the basic earnings per share from continuing and discontinued operations is based on profit from continuing and discontinued operations attributable to the equity holders of the parent for the nine months ended 30 September, 2005 of HK$1, 569, 286, 000 2004: HK$134, 230, 000 ; and the weighted average number of 2, 190, 644, ordinary shares 2004: 1, 992, 000, 000 ordinary shares ; in issue during the period. The calculation of the basic earnings per share from continuing operations is based on profit from continuing operations attributable to the equity holders of the parent for the nine months ended 30 September, 2005 of HK$76, 852, 000 2004: HK$66, 596, 000 ; and the weighted average number of 2, 190, 644, ordinary shares 2004: 1, 992, 000, 000 ordinary shares ; in issue during the period. No diluted earnings per share from continuing and discontinued operations or continuing operations for the nine months ended 30 September, 2005 has been calculated as all the convertible bonds and share options of the Company have been exercised during the period.
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The event and the premium for such insurance will be included in the entry fee. Where the organiser wishes to offer through the ACU Insurance Broker ; Third Party Insurance cover necessary to meet the Road Traffic Act requirements on Public Highways, this must be stated in the Supplementary Regulations. 3.22 Disclaimer It is a condition of acceptance of entry that the Organiser shall not be responsible for any damage to a motorcycle or its accessories, whether by fire, accident or other causes, nor for the theft of a motorcycle or its accessories, during the event. 3.23 Liability for Damage A rider is liable for any damage caused by himself, his passenger, or any helpers, during the event. The Organisers may act as agents for such persons to agree and pay for any damage and the riders shall on demand reimburse the Organisers any sum so paid. 3.24 Abandonment The Organisers reserve the right, subject to the approval of the Stewards of the Meeting, to cancel, postpone or abandon the competition, if circumstances should arise, which, in their opinion, render such action necessary. 3.25 Compliance with Regulations Every Entrant and Rider by entering or being entered or nominated thereby acknowledges that he is bound by the National Sporting Code of the ACU and these Standing Regulations, together with any Supplementary Regulations and Final Instructions to be hereafter issued, to all of which he undertakes to submit and moreover renounces any right to have recourse to any arbitrations or tribunal not provided for in the said Rules and Regulations. 3.26 Interpretation The interpretation of these Standing Regulations and the Supplementary Regulations or instructions to Riders will rest entirely with the Stewards of the Meeting whose decision shall be final and binding except as provided in the Sporting Code. 3.27 Fire Extinguishers All competitors with the exception of those travelling to an event on the machine on which they are competing, must have a 2kg minimum ; dry powder fire extinguisher available for immediate use. If a `closed vehicle' is being used the extinguisher must be fitted adjacent to, or on the inside of the working door. In the case of a shared vehicle the other competitors extinguisher s ; should also be visible, or, the fitted extinguisher s ; must be of a proportionately larger capacity. This fire extinguisher must be available at any refuelling point. 3.28 Power Washers Use of power washers is prohibited. Unless the organisers have suitable facilities which comply with the ACU Environmental Code. 4 4.1 4.1.2 ADDITIONAL STANDING REGULATIONS FOR SHORT COURSE ENDURO EVENTS Definition Multi lap short course event held under Enduro Standing Regulations and these variations. Entries As per 1.3 ; . The ratio of competitors to course will be 30 riders per kilometre of course e.g.180 riders must have 6kms lap distance etc. Sidecar: Half these figures. This recommended number may be changed by the authority granting the permit. Auto-Cycle Union Handbook 2007.
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