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8 Rothman ML, Hedrick SC, Bulcroft KA, et al. Effects of adult day health care on health outcomes and satisfaction with care. Med Care 1993; 31: 38 Rothman M, Farup C, Stewart W, et al. Symptoms associated with gastroesophageal reflux disease: development of a questionnaire for use in clinical trials. Dig Dis Sci, 2001; 46: 154048. Portenoy RK, Thaler HT, Kornblith AB, et al. The memorial symptom assessment scale. an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer 1994; 30A: 132636. Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life: a conceptual model of patient outcomes. JAMA 1995; 273: 59 American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. J Respir Crit Care Med 1995; 152 Suppl ; : S77120. 13 National Heart, Lung and Blood Institute & World Health Organization. Global Initiative for Chronic Obstructive Lung Disease [Internet]. Publication No. 2701A. Bethesda MD ; : US Department of Health and Human Services, Public Health Service, National Institutes of Health; 2001. Available from: : goldcopd workshop index . 14 Eltayara L, Becklace MR, Volta CA, et al. Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease. J Respir Crit Care Med 1996; 154 6 Pt 1 ; 172634. 15 Hajiro T, Nishimura K, Tsukino M, et al. Comparison of discriminative properties among disease-specific questionnaires for measuring health-related quality of life in patients with chronic obstructive pulmonary disease. J Respir Crit Care Med 1998; 157 3 Pt 1 ; 78590. 16 O-Donnell DE. Assessment of bronchodilator efficacy in symptomatic COPD: is spirometry useful? Chest 2000; 117: S427. 17 Bostrom C. Shoulder rotational strength, movement, pain and joint tenderness as indicators of upper-extremity activity limitation in moderate rheumatoid arthritis. Scand J Rehab Med 2000; 32: 1349. Lee CE, Simmonds MJ, Novy DM, et al. Selfreports and clinician-measured physical function among patients with low back pain: a comparison. Arch Phys Med Rehabil 2001; 82: 22731. Kaliner M. Allergy care in the next millennium: guidelines for the specialty. Presidential Address. J Allergy Clin Immunol 1997; 99: 72934. An evidence-based appraisal of reflux disease management--Genval Workshop Report. Gut 1999; 44 Suppl 2 ; : S116. 21 Boers M, Brooks P, Strand V, et al. The OMER.

Pyrimidine, an important ring system found in the nucleic acid, antibiotics, antimalarials, anticancer, anti-hiv, and anti-inflammatory drugs is associated with diverse biodynamic properties, and is of interest with context of drug development, because of its structure similarity to purines.

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