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For five years, she expected to come upon a report in a scientific or veterinary journal that already proved her point, but nothing surfaced. In a race against time and the possibility of competition, Mealey completed her preliminary work and published the results, thanks to the support she received from her WSU department chair, Dr. Richard DeBowes, and to the molecular biology skills of her research lab technician, Steve Bentjen. Says Mealey, "We were able to do the initial study on a very small budget, most of which came from a Washington State University faculty start-up package." As the research bore out, a strong heritability factor does play into ivermectin sensitivity. Dr. Mealey found three categories within the study's Collie population. One group inherits the gene that produces P-gp from both parents; these dogs will not be affected by ivermectin and will not pass on a gene for sensitivity. Another group inherits the gene for P-gp from one parent but not both; these dogs are also not ivermectinsensitive but do carry the gene for sensitivity. If bred to a dog with that same inheritance factor, the next-generation puppies will be sensitive to ivermectin. The final group does not inherit the gene that produces P-gp from either parent; these dogs will definitely be affected by ivermectin. Extrapolated to the general Collie population, that results in only. Therapy can be handled by either giving every dose directly observed, 5 days per week for 3 weeks or providing medication 7 days per week including weekend and holiday packets ; . Many providers report that introduction of packets detracts from the patient's acceptance of DOT and choose to medicate 5 days per week for 15 doses. After completion of the daily therapy portion of the Initiation Phase, the preferred drug regimen for pan-sensitive tuberculosis is twice weekly, directly observed therapy for the remainder of treatment. For those rare patients unable to tolerate the higher doses used for twice weekly therapy, daily therapy can be utilized. * Continuation Phase: After completing the Initiation Phase, the regimen should be changed to: INH and RIF administered twice weekly for 18 weeks or INH and RPT rifapentine ; administered once weekly for 18 weeks eligible patients only ; . Treatment should be extended in specific circumstances see Table 12 ; . The standard treatment regimen for Maryland should be utilized routinely. There are several additional dosing options which can be utilized when clinically indicated see Appendix B and buspar. 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